Primordial germ cell Protection Boots (PGC) specification occurs early in development.PGC specifiers have been identified in Drosophila, mouse, and human but remained elusive in most animals.Here we identify the RNA-binding protein Dnd as a critical PGC specifier in the medaka fish (Oryzias latipes).Dnd depletion specifically abolished PGCs, and it
Background: Tuberculosis (TB) remains a major cause of morbidity and mortality worldwide.Problem of Latent Tuberculosis Infection (LTBI) is increasing in number especially in countries with high TB incidence rate, such as Indonesia.Although not every LTBI will become active TB, if untreated and not handled appropriately it can still be a source of
The blood-tumor barrier (BTB) restricts the efficient delivery of anti-glioma drugs to cranial glioma tissues.Increased BTB permeability may allow greater delivery of the therapeutic agents.Increasing evidence has revealed that PIWI proteins and PIWI-interacting RNAs (piRNAs) play an important role in tumor progression.However, whether PIWI protein
Agricultural pests can cause direct damage to crops, including chlorosis, loss of vigor, defoliation, and wilting.In addition, they can also indirectly damage plants, such as by transmitting pathogenic micro-organisms while feeding on plant tissues, affecting the productivity and quality of crops and interfering with agricultural production.Among t